Coco Gauff got off to a poor start but came back to defeat Dayana Yastremska 0-6, 6-2, 7-5 in a second-round match.
It was only the second time Gauff won after losing the first set 6-0 in WTA-level events. She had done it against Elise Mertens four years ago.
The fourth-ranked Gauff needs two more victories to reach the quarterfinals for her best appearance in five outings in Madrid. She will next face fellow American Ann Li, who defeated Leylah Fernandez 6-4, 3-6, 6-4.
Earlier Thursday, world No. 7 Mirra Andreeva, who will turn 18 on Tuesday, reached the third round by defeating Marie Bouzkova 6-3, 6-4, while Brazil’s Bia Haddad Maia rallied to beat Bernard Pera 2-6, 6-3, 6-1.
American Katie Volynets lost 6-1, 6-2 to Diana Shnaider, and countrywoman Emma Navarro won 7-5, 7-5 against Maya Joint.
In the men’s side, former world No. 4 Kei Nishikori defeated Alexsandar Vukic 6-4, 3-6, 6-3 for his 450th tour-level win. The 64th-ranked Japanese was a 2014 finalist in Madrid.
“I had no idea,” the 35-year-old Nishikori said about his milestone. “I just try to play one match at a time. It’s a lot, yes… I have played for 18 years now, hopefully I can reach 500 (wins).”