Ealing’s win was the only upset of the day as Premiership sides beat second-tier opponents in the day’s other five matches.
Gloucester had the nerviest afternoon as they won 31-26 at close neighbours Hartpury.
The Cherry and Whites led 26-14 at half-time having secured a four-try bonus point before the break.
A penalty try with nine minutes to go gave Hartpury hope as Gloucester had Freddie Clarke and Josh Hathaway sent to the sin-bin, but the Championship side could not find what could have been a winning try as Gloucester join Exeter at the top of Pool E.
Harlequins also won at near neighbours as Hayden Hyde scored twice in their 35-22 win over London Scottish at the Richmond Athletic Ground.
Newcastle returned from the Wirrall with a bonus point in Pool A after a 33-12 win at Caldy while Bristol cruised to a 67-19 win over Bedford at Ashton Gate in their Pool D match.
Kalaveti Ravouvou and Harry Thacker each scored two tries as the Bears scored seven tries in the first half and four after the break.
But Bath claimed the biggest win of the day as they thrashed Ampthill 73-0 at Dillingham Park.
Kepu Tuipulotu scored a first-half hat-trick while Ruaridh McConnochie and Ethan Staddon crossed twice as the Premiership side scored 11 tries.
It put them top of Pool D ahead of Bristol on points difference as the first round of games came to a close.
