England have made extensive alterations to their team with four personnel changes and a further three positional ones.
Marcus Smith returns at full-back and Tom Roebuck comes in on the right wing with Tommy Freeman switching to centre in the wake of Ollie Lawrence’s Achilles injury. Elliot Daly shifts from 15 to the left wing.
In the forwards, Luke Cowan-Dickie replaces Jamie George at hooker and Ben Curry is selected ahead of Tom Willis. The final positional switch sees Ben Earl move to number eight. Henry Pollock, the 20-year-old Northampton flanker, could make his debut off the bench, while veteran fly-half George Ford is in line for his first appearance of the Championship.
England: 15-Smith, 14-Roebuck, 13-Freeman, 12-Dingwall, 11-Daly; 10-F Smith, 9-Mitchell; 1-Genge, 2-Cowan-Dickie, 3-Stuart, 4-Itoje (capt), 5-Chessum, 6-T Curry, 7-B Curry, 8-Earl.
Replacements: 16-George, 17-Baxter, 18-Heyes, 19-Cunningham-South, 20-Pollock, 21-Willis, 22-Van Poortvliet, 23-Ford